Introducing Bloom Hemp Advanced Immunity Softgels, featuring non-impairing phytocannabinoids such as CBD, CBDA, CBG, and CBGA. These softgels are designed to enhance your immune system this fall and winter and can be taken year-round keeping your immune system strong. Better yet, these offer relief from inflammation and anxiety without the side effects of pharmaceuticals.

In today’s health-conscious world, more people are seeking natural ways to enhance their immune system. Cannabinoids like cannabidiol (CBD), cannabidiolic acid (CBDA), cannabigerol (CBG), and cannabigerolic acid (CBGA) have gained attention for their potential health benefits. Emerging research suggests these compounds may play significant roles in enhancing immunity, modulating stress responses, relieving pain, and supporting overall wellness by interacting with the endocannabinoid system (ECS).

Enhancing Immunity
Cannabinoids, particularly CBD and CBG, have been noted for their immunomodulatory properties. According to research by Zhou et al. (2018), both cannabinoids influence the immune response by interacting with CB2 receptors found in immune cells. This interaction helps regulate immune function and maintain a balanced immune response, potentially protecting against overreactions that lead to autoimmune diseases.

Emerging Cannabinoids in Health, Wellness, and Covid-19 Recovery
Cannabidiolic acid (CBDA) and cannabigerolic acid (CBGA) are lesser-known compounds found within the raw cannabis sativa plant, both of which may have exciting effects on the world of health and wellness based on early-stage recent research. In fact, some experts consider these compounds the next frontier when it comes to cannabinoid-based therapy—expanding the potential development of anti-inflammatory medications that are not only more therapeutically effective but also less likely to cause unwanted side effects and/or long-term dependency than current options. CBDA and CBGA may even protect against the Covid-19 virus and expedite recovery for those infected.

Modulating Stress Response and Providing Relief
The role of cannabinoids in modulating stress responses is another significant area of interest. CBD, CBG, and CBDA for example, have shown promise in reducing anxiety through its interaction with the 5-HT1A serotonin receptor. A study by Russo et al. (2024) demonstrates that these cannabinoids possess significant anti-anxiety effects without producing major side effects typical of conventional pharmaceuticals.

Anti-inflammatory Properties and Pain Relief
Inflammation is a natural defense mechanism of the immune system, but chronic inflammation can lead to various health issues. Cannabinoids like CBG possess potent anti-inflammatory properties which can help in managing conditions like arthritis and inflammatory bowel disease (IBD). Borrelli et al. (2013) found that CBG interacts with CB1 and CB2 receptors to exert anti-inflammatory effects, reducing symptoms associated with multiple inflammatory conditions. The analgesic properties of CBD are well-documented. CBD interacts with neurotransmitters and endocannabinoid receptors to alleviate chronic pain. This mechanism is highlighted in a study by Boyaji et al. (2020), where CBD showed notable efficacy in pain management without the risk of dependency associated with opioids.

Animal studies indicate that CBDA may be more potent than CBD, not only because of its superior absorption but also due to its more effective interactions within the body to relieve symptoms such as nausea, vomiting, pain, inflammation, and seizures. Unlike CBD, CBDA primarily functions by inhibiting the COX-2 enzyme, highlighting a distinct mechanism of action within the endocannabinoid system. A deeper understanding of these compounds could lead to significant advancements in therapeutic applications, ultimately enhancing health outcomes.

Supporting the Endocannabinoid System (ECS) for Whole Person Health
The endocannabinoid system (ECS) plays a vital role in maintaining homeostasis, affecting processes such as mood, sleep, appetite, and immune function. CBD and the other minor cannabinoids enhance the functioning of the ECS by inhibiting the breakdown of endocannabinoids like anandamide, promoting a balanced internal environment. This regulatory effect supports overall well-being and health across all organ systems, the immune system and all of the other neurotransmitter signaling systems to bring homeostasis or balance for optimal health and wellness.

The therapeutic potential of CBD, CBDA, CBG, and CBGA is significant, especially in areas such as immune enhancement, stress modulation, inflammation reduction, and support for the endocannabinoid system (ECS). These cannabinoids, through their interaction with various receptors and neurotransmitters, offer multifaceted benefits that could address numerous health challenges. Ongoing research continues to underscore the significant promise these compounds hold, paving the way for their integration into clinical practices for more holistic health management.

Summary of Benefits and Research of Bloom Hemp Advanced Immunity with
CBD / CBDA / CBG / CBGA

CBD Properties and Effects
CBD is a versatile molecule that interacts with various cell receptors across the body, leading to both direct and indirect biological changes in our physical health, mental state, and emotional well-being. CBD works on over 70 targets within the body and is the most abundant non-impairing cannabinoid in the plant.

CBDA Properties and Effects

• Anti-amyloid (with relevance to Alzheimer’s disease)
  • Anti-amyloid beta (THCA reduced levels) (J. Kim et al., 2023)
  • Anti-amyloid tau (THCA reduced levels) (J. Kim et al., 2023)
• Anti-cancer
  • Anti-metastatic (breast cancer cells) (S. Takeda et al., 2014)
  • Antiemetic (D. Bolognini et al., 2013); reduces chemotherapy-induced nausea and vomiting (E. Rock et al., 2022 – Link: http://researchgate.net/publication/362810151_Evaluation_of_Sex_Differences_in_the_Potential_of_D_9_-Tetrahydrocannabinol_Cannabidiol_Cannabidiolic_Acid_and_Oleoyl_Alanine_to_Reduce_Nausea-Induced_Conditioned_Gaping_Reactions_in_Sprague-Dawley_Ra)
• Anti-inflammatory (reduces biomarkers of stress and inflammation in cattle) (M. Kleinhenz et al., 2022)
• Anti-obesity (ameliorates obesity and associated metabolic abnormalities (E. Ben-Cnaan et al., 2022; E. D’Aniello et al., 2019)
• Antipruritic (decreases itching in dogs with atopic dermatitis when administered with CBD) (M. Loewinger et al., 2022 – Link: http://onlinelibrary.wiley.com/doi/10.1111/vde.13077)
• Anti-viral (may prevent and treat SARS-CoV-2 infection) (R. van Breemen et al., 2022)

Cannabigerol (CBG) Properties and Effects

• Anti-aging (healthy skin-promoting agent) (E. Perez et al., 2022; M. Luz-Veiga et al., 2023)
• Analgesia – Relieves Pain
  • Antinociceptive (Y. Wen et al., 2023)
  • Drug-induced peripheral neuropathies (D. Sepulveda et al., 2022)
• Anti-cancer (in cases of colon cancer) (F. Borelli et al., 2014)
  • Apoptotic in cases of colon cancer (F. Borelli et al., 2014); in cases of cholangiocarcinoma (R. Carpasso et al., 2022)
  • Antitumoral (in cases of glioblastoma T. Lah et al., 2021), (in cases of melanoma I. Wyrobnik et al., 2023)
• Antibacterial
  • Antibacterial (potent activity against MRSA) (G. Appendino et al., 2008)
  • Antibacterial (potent activity against S. mutans associated with dental caries) (M. Aqawi et al., 2021)
• Anti-depressant (E. Russo et al., 2022 – Link: https://www.liebertpub.com/doi/abs/10.1089/can.2021.0058)
• Anti-anxiety (E. Russo et al., 2024)
• Anti-inflammatory (in IBD/colitis F. Borelli et al., 2013), (in rheumatoid arthritis (T. Lowin et al., 2023)
• Anti-fibrotic (N. Aljobailey et al., 2023)
• Anti-oxidant (A. Dawidowicz et al., 2012)
• Antiviral – SARS-CoV-2 Blocks COVID-19 and other variants from cellular entry (R. van Breemen et al., 2022)
• Appetite stimulant (D. Brierley et al., 2016)
• Bladder control (CBG reduces bladder contractility E. Pagano et al. 2015)
• Blood pressure lowering (V. Vernail et al., 2022)
• IOP-lowering agent (reduces intraocular pressure in glaucoma) (B. Colasanti 2009 – Link: https://www.liebertpub.com/doi/abs/10.1089/jop.1990.6.259)
• Neuroprotective (with potential relevance to Huntington’s disease) (S. Valdeolivas et al., 2015)
• Wound healing -Neuro-regenerative (A. Valeri et al., 2022)

CBGA Properties and Effects

• Anti-bacterial (CBGA reduces bacteria that cause dental plaque better than leading toothpaste) (V. Stahl et al., 2020)
• Anti-epileptic (CBGA demonstrated a potent anti-epileptic effect. However, high dosage induced pro-seizure effects (L. Anderson et al., 2021)
• Anti-viral (CBGA may prevent and treat SARS-CoV-2 infection) (R. van Breemen et al., 2022)

Ready to explore the benefits of Bloom Hemp Advanced Immunity for your immune health? Click here to learn more or shop using Immunity20 for 20% off.

If you need help choosing or need advice on what to start with contact us on our Free Nurse Line at 970-404-HOPE (4673). Bloom Hemp also offers Free Nursing Care Plans on our service tab.

Blog Resources

• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165946/
• https://pubmed.ncbi.nlm.nih.gov/35007072/
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938896/
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877694/
• https://pubmed.ncbi.nlm.nih.gov/32483052/
• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110442/
• https://pubmed.ncbi.nlm.nih.gov/23415610/
• https://pubmed.ncbi.nlm.nih.gov/31980957/
• https://cannakeys.com/cannabidiolic-acid-cbd-a-cannabinoid-research/
• https://cannakeys.com/cannabidiol-cbd-cannabinoid-research
• https://cannakeys.com/cannabigerol-cbg-cannabinoid-research
• https://cannakeys.com/cannabigerolic-acid-cbg-a-cannabinoid-research