THC is a multi-target molecule that binds with numerous cell receptors throughout the body; thus, it directly and indirectly initiates complex biological changes in the body, mind, and emotion. THC was discovered in 1964, and is primarily responsible for many therapeutic and adverse mind-altering effects of the plant.
When THC binds with CB1 and CB2 receptors it also co-activates the endocannabinoidome which includes enzymes, neurotransmitters,
either in part or significantly, a diverse group of receptor sites, enzymes, hormones, and other signaling pathways that affect the body and mind.